TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Affinity DataIC50: 0.280nMAssay Description:Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Inhibition of EGFR (unknown origin) using tyrosine 4 as substrate by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q2ZG6W79PubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q2ZG6W79PubMedDrugBank
MMDB
PDB
3D Structure (crystal)
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Affinity DataIC50: 0.730nMAssay Description:Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Affinity DataIC50: 0.840nMAssay Description:Inhibition of human recombinant cytoplasmic His-tagged FGFR2 (403 to 822 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by FRET-ba...More data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Affinity DataIC50: 0.900nMAssay Description:Inhibition of Bcr-Abl T315I mutant (unknown origin) using Tyr2 peptide substrate after 2 hrs by FRET-based Z'-lyte assayMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Affinity DataIC50: 0.910nMAssay Description:Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Affinity DataIC50: 0.990nMAssay Description:Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of EGFR (unknown origin) using tyrosine 4 as substrate by fluorescence analysisMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of wild type Bcr-Abl (unknown origin) using Tyr2 peptide substrate after 2 hrs by FRET-based Z'-lyte assayMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human recombinant cytoplasmic His-tagged FGFR2 (403 to 822 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by FRET-ba...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human recombinant cytoplasmic His-tagged FGFR2 (403 to 822 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by FRET-ba...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human recombinant cytoplasmic His-tagged FGFR2 (403 to 822 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by FRET-ba...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human recombinant cytoplasmic His-tagged FGFR2 (403 to 822 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by FRET-ba...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human recombinant cytoplasmic His-tagged FGFR2 (403 to 822 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by FRET-ba...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human recombinant cytoplasmic His-tagged FGFR2 (403 to 822 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by FRET-ba...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human recombinant cytoplasmic His-tagged FGFR2 (403 to 822 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by FRET-ba...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human recombinant cytoplasmic His-tagged FGFR2 (403 to 822 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by FRET-ba...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Affinity DataIC50: 2.40nMAssay Description:Inhibition of human recombinant cytoplasmic His-tagged FGFR2 (403 to 822 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by FRET-ba...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Affinity DataIC50: 2.60nMAssay Description:Inhibition of human recombinant cytoplasmic His-tagged FGFR2 (403 to 822 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by FRET-ba...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Affinity DataIC50: 2.70nMAssay Description:Inhibition of human recombinant cytoplasmic His-tagged FGFR2 (403 to 822 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by FRET-ba...More data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of wild type Bcr-Abl (unknown origin) using Tyr2 peptide substrate after 2 hrs by FRET-based Z'-lyte assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant B-Raf V600E mutant by FRET-based Z'-lyte assayMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Affinity DataIC50: 3.10nMAssay Description:Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Affinity DataIC50: 3.5nMAssay Description:Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Affinity DataIC50: 3.60nMAssay Description:Inhibition of human recombinant cytoplasmic His-tagged FGFR2 (403 to 822 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by FRET-ba...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Affinity DataIC50: 3.70nMAssay Description:Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Affinity DataIC50: 4.60nMAssay Description:Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of EGFR (unknown origin) using tyrosine 4 as substrate by fluorescence analysisMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of wild type Bcr-Abl (unknown origin) using Tyr2 peptide substrate after 2 hrs by FRET-based Z'-lyte assayMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Affinity DataIC50: 5.10nMAssay Description:Inhibition of human recombinant His-tagged FGFR3 cytoplasmic domain (399 to 806 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Affinity DataIC50: 5.10nMAssay Description:Inhibition of human recombinant His-tagged FGFR3 cytoplasmic domain (399 to 806 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Affinity DataIC50: 5.40nMAssay Description:Inhibition of human recombinant His-tagged FGFR3 cytoplasmic domain (399 to 806 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant His-tagged FGFR3 cytoplasmic domain (399 to 806 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ...More data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of Bcr-Abl T315I mutant (unknown origin) using Tyr2 peptide substrate after 2 hrs by FRET-based Z'-lyte assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant human COX-2 preincubated for 15 mins followed by fluorometric substrate/heme addition for 15 mins subsequently incubated wi...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant His-tagged FGFR3 cytoplasmic domain (399 to 806 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ...More data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of Bcr-Abl T315I mutant (unknown origin) using Tyr2 peptide substrate after 2 hrs by FRET-based Z'-lyte assayMore data for this Ligand-Target Pair